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GLP-1 drugs like Ozempic have become quite popular, especially as weight-loss aids. However, they do have certain drawbacks, like rebound weight gain and loose skin. Not much is known about their side effects in older people. However, people over 65 tend to be more prone to drug side effects in general. Experts say, with proper supervision, these drugs are truly remarkable in this population. GLP-1 drugs include the various brands of semaglutide (Ozempic, Rybelsus, Wegovy) as well as dulaglutide (Trulicity), exenatide (Bydureon, Byetta), liraglutide (Victoza, Saxenda), lixisenatide (Adlyxin), and tirzepatide (Mounjaro). See full list on healthline.com Dina Peralta-Reich, M.D., FAAP, FOMA, and Director of New York Weight Wellness Medicine, says a potential risk that is associated with these medications in people over the age of 65 is dehydration. Monitoring water intake can be challenging, and it is crucial to avoid dehydration, which may result in dizziness, falls, fainting, and possibly fractures, she said. Additionally, she said that the gastrointestinal side effects of these medications, like nausea and vomiting, may be worse in older people, which may set them up for dehydration, weakness, or nutritional deficiencies. Peralta-Reich further advised that anyone using these medications should be supervised by a specialist. As an obesity medicine specialist, our primary objective is to ensure successful weight loss while also safeguarding against the loss of muscle mass, she explained. Jill Barat, Pharm.D., a licensed pharmacist with Pharmedico Pharmacy, added, Muscle loss isnt a good thing for anyone, but this can be especially dangerous for older people as it may put them at higher risk of falls which can lead to broken bones. Peralta-Reich suggests that close monitoring is important for older patients especially if they have other health conditions, such as high blood pressure, diabetes, and hormonal deficiencies since dosage may change over the course of treatment. See full list on healthline.com Peralta-Reich commented that she feels these drugs are truly remarkable, provided the patient has oversight from a board-certified obesity medicine specialist. Regardless of age, the risks associated with being overweight or obese remain significant, she said. By effectively reducing body fat percentage and visceral fat, people can substantially lower the chances of developing other comorbidities. Dr. Michael Russo, a Bariatric Surgeon at Smart Dimensions in Orange County, California, cautioned, however, that drugs like Ozempic are not a quick fix. This medication needs to be coupled with lifestyle changes in order to not only get the best results but to minimize the chance of weight regain in the future, he advised. As a word of encouragement, Peralta-Reich noted that the age of 65 is no longer considered to be old. [I]t presents an excellent opportunity to take charge of ones health and weight in a safe and effective manner, she said. Embracing a healthier lifestyle can lead to positive outcomes at any age! See full list on healthline.com It should be noted, however, that drugs like Ozempic are not always available to patients due to their expense and the fact that many insurance companies are not opting to cover them, especially for weight loss. When it comes to the management of Type 2 diabetes, Dr. Kezia Joy, Medical Content Advisor for Welzo, said there are several alternatives to the GLP-1 drugs, including: Metformin DPP-4 inhibitors SGLT2 inhibitors Insulin therapy See full list on healthline.com GLP-1 drugs like Ozempic have become quite popular, especially as weight-loss aids. However, they do have certain drawbacks, like rebound weight gain and loose skin. Not much is known about their side effects in older people. However, people over 65 tend to be more prone to drug side effects in general. See full list on healthline.com View all Learn how GLP-1 medications (semaglutide or tirzepatide) can help older adults lose weight, protect the heart, and minimize risks like sarcopenia and falls. This guide explains how to use GLP-1s safely after 65: modified dosing, muscle preservation protocols, Medicare coverage coming 2026, monitoring requirements, and when GLP-1s may not be appropriate despite obesity. Show more GLP-1 medications are an effective way to manage blood sugar, improve heart health, and treat obesity, but there are certain considerations to take into account for older adults. GLP-1 medications can be effective for weight loss after 60, but older adults face unique considerations around muscle loss, bone density, and drug interactions. Best GLP-1 for seniors: compare the top programs and medications, see 65+ safety data, Medicare coverage rules, and the muscle-loss prevention plan.