People prescribed the popular GLP-1 weight-loss drugs such as Ozempic and Mounjaro may experience benefits such as increased cognitive and behavioral health, according to scientists at WashU Medicine and the Veterans Affairs St. Louis Health Care System.
According to new research, GLP-1 medications cause modest and normal muscle loss, but strength appears to remain stable, and fat loss dramatically outpaces any muscle loss.
Factors Affecting Weight Loss Results with GLP-1 Agonists. Weight loss does not follow a one-size-fits-all approach. Each person responds differently to GLP-1 medications due to a range of unique factors.

GLP-1 weight loss: Explore the science behind GLP-1 medications, how they help with weight loss, and what patients should know about these treatments.
Get access to GLP-1 weight loss medications with Noom Med. Starting at $149, you can lose up to 20% of your body weight with clinically proven and trusted medications.

While GLP-1 medications dont directly increase your BMR, they do improve parts of your metabolic health.Weight loss blog Deep dives into nutrition, science, and lifestyle. GLP-1 nutrition guide What to eat for maximum results and minimal side effects.
Rapid weight loss from any cause involves losing some lean tissue along with fat, and GLP-1 agonists are no exception. The proportion of lean mass lost relative to total weight loss varies widely across studies, ranging from as low as 15% to as high as 40 to 60% of total weight lost.
"I haven't really prescribed them for weight loss much," she told me. "Have you tried Noom? Or meals from HelloFresh?" But I'm a primary care doctor, and I'd been following the scientific literature that showed GLP-1 agonists could now be used specifically for weight loss.